9NTP image
Deposition Date 2025-03-18
Release Date 2026-07-29
Last Version Date 2026-07-29
Entry Detail
PDB ID:
9NTP
Keywords:
TRANSFERASE
Title:
EGFR kinase domain (T790MV948R) in complex with a strain-release covalent inhibitor
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.55 Å
R-Value Free:
0.20
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
P 1 2 1
9NTP validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Epidermal growth factor recep
Gene (Uniprot):EGFR
Chain IDs:A
Chain Length:329
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P00533 Pfam ID:PF07714 EC:2.7.10.1
Ligand Molecules
A1B6E
EDO
Primary Citation
Late-stage functionalization with strain-release warheads enables tunable covalent inhibition
Science ? ? ? (2026)
DOI: 10.1126/science.adx7219
Primary Citation of related structures
9NTP
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