9NSI image
Deposition Date 2025-03-17
Release Date 2026-09-30
Last Version Date 2026-09-30
Entry Detail
PDB ID:
9NSI
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of GLP-1R-Gs complex with GLP-1 (9-36) and cpd19
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Trichoplusia ni, Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9NSI validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAS
Mutagens:multiple
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P63092 Pfam ID:PF00503
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873 Pfam ID:PF25391
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:C (auth: G)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768 Pfam ID:PF00631
Polymer Type:polypeptide(L)
Molecule:Nb35
Chain IDs:D (auth: N)
Chain Length:0
Number of Molecules:1
Biological Source:Lama glama
Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide-1-(9-36
Chain IDs:E (auth: P)
Chain Length:0
Number of Molecules:1
Biological Source:synthetic construct
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Glucagon-like peptide 1 recep
Gene (Uniprot):GLP1R
Chain IDs:F (auth: R)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P43220 Pfam ID:PF02793, PF00002
Ligand Molecules
A1B0V
Primary Citation
Cryo-EM structure of GLP-1R-Gs complex with GLP-1 (9-36) and cpd19
To Be Published ? ? ? (?)
Primary Citation of related structures
9NSI
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