ISDA: 9NPM

Deposition Date 2025-03-11

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9NPM

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Composite map of three pairs of dimeric VRC36 Fabs bound to HIV-1 BG505.T332N DS-SOSIP.664 Env trimer

Biological Source:

Source Organism(s):

Human immunodeficiency virus 1 (Taxon ID: 11676)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.59 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:HIV-1 BG505.T332N DS-SOSIP.66
Chain IDs:A (auth: C), G (auth: E), M (auth: A)
Chain Length:473
Number of Molecules:3
Biological Source:Human immunodeficiency virus 1

Polymer Type:polypeptide(L)
Molecule:HIV-1 BG505.T332N DS-SOSIP.66
Chain IDs:B (auth: D), H (auth: F), N (auth: B)
Chain Length:153
Number of Molecules:3
Biological Source:Human immunodeficiency virus 1

Polymer Type:polypeptide(L)
Molecule:VRC36 Fab heavy chain
Chain IDs:C (auth: K), E (auth: M), I (auth: O), K (auth: Q), O (auth: G), Q (auth: I)
Chain Length:223
Number of Molecules:6
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:VRC36 Fab light chain
Chain IDs:D (auth: L), F (auth: N), J (auth: P), L (auth: R), P (auth: H), R (auth: J)
Chain Length:214
Number of Molecules:6
Biological Source:Homo sapiens

Ligand Molecules

NAG

Primary Citation

Composite map of three pairs of dimeric VRC36 Fabs bound to HIV-1 BG505.T332N DS-SOSIP.664 Env trimer

Cheng, J, Cale, E.M, Longo, N, Sutton, M.S, Lei, H, Huang, R, Morton, A.J, Lang, Z.C, Morano, N.C, Roark, R.S, Becker, J.E, Tsybovsky, Y, Li, N, Zhang, B, Du, H, Rubin, S, Shapiro, L, Pierson, T.C, Doria-Rose, N.A, Zhou, T, Kwong, P.D.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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