ISDA: 9NFP

Deposition Date 2025-02-21

Release Date 2025-12-03

Last Version Date 2026-04-01

Entry Detail

PDB ID:

9NFP

Keywords:

VIRAL PROTEIN

Title:

Structure of SARS-CoV-2 NSP14 bound to N-((4-cyclopropylthiazol-2-yl)methyl)-1H-pyrazole-3-carboxamide

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.23

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine-N7 methyltransferase
Gene (Uniprot):rep
Chain IDs:A
Chain Length:523
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF06471 EC:2.7.7.48

Ligand Molecules

A1BXZ

PO4

Primary Citation

Fragment-Based Development of NSP14 Exonuclease Inhibitors Confounded by Batch-to-Batch Variability.

Coker, J.A, Sun, R, Polzer, P.M, Romigh, T, Goins, C.M, Wang, N.S, Jung, J.U, Stauffer, S.R.Show

ACS Chem. Biol. 21 413 418 (2026)

PMID: 41698876 DOI: 10.1021/acschembio.5c00930

Primary Citation of related structures

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