9N29 image
Deposition Date 2025-01-28
Release Date 2026-07-15
Last Version Date 2026-07-15
Entry Detail
PDB ID:
9N29
Title:
hM4Di(GRANPA) in complex with mGsI and diphenhydramine
Biological Source:
Source Organism(s):
Rattus norvegicus (Taxon ID: 10116)
Homo sapiens (Taxon ID: 9606)
Lama glama (Taxon ID: 9844)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.60 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:D (auth: A)
Chain Length:245
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):Gnb1
Chain IDs:A (auth: B)
Chain Length:351
Number of Molecules:1
Biological Source:Rattus norvegicus
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:B (auth: G)
Chain Length:68
Number of Molecules:1
Biological Source:Homo sapiens
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:nanobody 35
Chain IDs:C (auth: N)
Chain Length:138
Number of Molecules:1
Biological Source:Lama glama
Polymer Type:polypeptide(L)
Molecule:Muscarinic acetylcholine rece
Gene (Uniprot):CHRM4
Chain IDs:E (auth: R)
Chain Length:478
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
Primary Citation
Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent.
Signal Transduct Target Ther 11 ? ? (2026)
PMID: 42393022 DOI: 10.1038/s41392-026-02865-4
Primary Citation of related structures
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