ISDA: 9MYS

Deposition Date 2025-01-22

Release Date 2026-09-09

Last Version Date 2026-09-09

Entry Detail

PDB ID:

9MYS

Keywords:

TRANSFERASE

Title:

The cryo-EM structure of the mutant MHKKKQ DNMT1-umNCP complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Xenopus laevis (Taxon ID: 8355)
Escherichia coli (Taxon ID: 562)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.93 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA (cytosine-5)-methyltransf
Gene (Uniprot):DNMT1
Chain IDs:A
Chain Length:1250
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P26358 Pfam ID:PF12047, PF02008, PF01426, PF00145 EC:2.1.1.37

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H2A
Gene (Uniprot):LOC494591
Chain IDs:B (auth: N), H (auth: n)
Chain Length:130
Number of Molecules:2
Biological Source:Xenopus laevis

UniProt ID:Q6AZJ8 Pfam ID:PF00125, PF16211

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H2B 1.1
Chain IDs:C (auth: O), I (auth: o)
Chain Length:123
Number of Molecules:2
Biological Source:Xenopus laevis

UniProt ID:P02281 Pfam ID:PF00125

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H3
Gene (Uniprot):LOC121398065
Chain IDs:D (auth: P), J (auth: p)
Chain Length:136
Number of Molecules:2
Biological Source:Xenopus laevis

UniProt ID:A0A310TTQ1 Pfam ID:PF00125

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone H4
Chain IDs:E (auth: Q), K (auth: q)
Chain Length:103
Number of Molecules:2
Biological Source:Xenopus laevis

UniProt ID:P62799 Pfam ID:PF15511

Polymer Type:polydeoxyribonucleotide
Molecule:Nucleosome 601 DNA (149-MER)
Chain IDs:F (auth: X)
Chain Length:149
Number of Molecules:1
Biological Source:Escherichia coli

Polymer Type:polydeoxyribonucleotide
Molecule:Nucleosome 601 DNA (149-MER)
Chain IDs:G (auth: Y)
Chain Length:149
Number of Molecules:1
Biological Source:Escherichia coli

Modified Residue