ISDA: 9MIX

Deposition Date 2024-12-13

Release Date 2026-08-05

Last Version Date 2026-08-05

Entry Detail

PDB ID:

9MIX

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of human NBCn2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.85 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Sodium-driven chloride bicarb
Gene (Uniprot):SLC4A10
Chain IDs:A, B
Chain Length:981
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q6U841 Pfam ID:PF07565, PF00955

Ligand Molecules

CLR

NAG

Primary Citation

Structural insights enable drug discovery for the neuronal NBCn2 carbonate transporter

Yang, S, Zhao, Y, Vatansever, S, Zilberg, G, Capper, M.J, Zhang, J, Stamos, J, Hutchinson, K, Warren, A.L, Stone, A.C, Abbassi, A, Purisic, E, Ho, L, Li, A, Dai, J, Schlessinger, A, Zhang, B, Wacker, D.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-75444-4

Primary Citation of related structures

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