ISDA: 9M7G

Deposition Date 2025-03-10

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

9M7G

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of the human glucagon receptor (GCGR) in ligand free state resolved via the fusion/crosslinking strategy

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Aequorea victoria (Taxon ID: 6100)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.38 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Glucagon receptor
Chain IDs:A
Chain Length:476
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Green fluorescent protein
Chain IDs:B
Chain Length:196
Number of Molecules:1
Biological Source:Aequorea victoria

Polymer Type:polypeptide(L)
Molecule:GFP-clamp E186C
Chain IDs:C
Chain Length:294
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

Cryo-EM structure determination of GPCRs with disulfide-crosslinked fusion protein

Han, S.C, Li, M.H.Show

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