ISDA: 9LWI

Deposition Date 2025-02-15

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9LWI

Keywords:

ANTIVIRAL PROTEIN

Title:

The head region of HBx-Smc5/6 ubiquitination complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Hepatitis B virus (Taxon ID: 10407)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.12 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Structural maintenance of chr
Chain IDs:A
Chain Length:1091
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96SB8

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Gene (Uniprot):DDB1
Chain IDs:B
Chain Length:1140
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q16531

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein X
Chain IDs:C
Chain Length:154
Number of Molecules:1
Biological Source:Hepatitis B virus

UniProt ID:Q2F514

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:EP300-interacting inhibitor o
Chain IDs:D
Chain Length:333
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8N140

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Non-structural maintenance of
Gene (Uniprot):NSMCE3
Chain IDs:E
Chain Length:304
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96MG7

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Non-structural maintenance of
Gene (Uniprot):NSMCE1
Chain IDs:F
Chain Length:266
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8WV22

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cullin-4A
Gene (Uniprot):CUL4A
Chain IDs:G
Chain Length:760
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13619

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase R
Gene (Uniprot):RBX1
Chain IDs:H
Chain Length:108
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62877 EC:2.3.2.27

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Structural maintenance of chr
Chain IDs:I
Chain Length:1101
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8IY18

Ligand Molecules

Primary Citation

Structural and functional insights into HBx-Smc6 targeting for HBV inhibition.

Cheng, T, Zhou, J, Huang, W, Du, L, He, P, Yang, R, Gao, Y, Hao, M, Hu, K, Chen, J, Wang, H, Rao, Z, Yuan, Z, Wang, L.Show

Cell Res. ? ? ? (2026)

PMID: 41991645 DOI: 10.1038/s41422-026-01251-7

Primary Citation of related structures

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