ISDA: 9L69

Deposition Date 2024-12-24

Release Date 2026-07-01

Last Version Date 2026-07-01

Entry Detail

PDB ID:

9L69

Keywords:

DNA BINDING PROTEIN

Title:

Structure of the human cGAS with 2'3'-cGUMP

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.09 Å

R-Value Free:

0.27

R-Value Work:

0.23

Space Group:

P 21 21 21

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Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cyclic GMP-AMP synthase
Chain IDs:A, B
Chain Length:522
Number of Molecules:2
Biological Source:Homo sapiens

Ligand Molecules

A1EIP

Primary Citation

Human cGAS synthesizes cyclic GMP-UMP to activate the STING signaling pathway

Zhou, R, Zhan, X, Zhang, Z, Shi, Y.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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