ISDA: 9K91

Deposition Date 2024-10-25

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

9K91

Keywords:

HYDROLASE

Title:

Cryo-EM structure of human histone deacetylase 6 tandem catalytic domain (HDAC6 CD1-2)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.86 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone deacetylase 6
Gene (Uniprot):HDAC6
Chain IDs:A
Chain Length:763
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UBN7 Pfam ID:PF00850 EC:3.5.1.98

Ligand Molecules

Primary Citation

Hydrogen sulfide binds to the zinc-active-site of hHDAC6 to increase enzyme activity via an H2S-mediated deacetylation pathway

Sun, C, Wang, Y, Cai, S, Xie, K, Li, M, Zhu, Z, Chao, Y, Zhou, Z, Chen, Y, Xue, W, Mu, X, Bian, X, Miao, W, Wu, J, Ding, Q, Wang, M, Tao, B, Zhang, I, Zhu, Y, Qu, Q, Zhu, Y.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form