ISDA: 9J5L

Deposition Date 2024-08-12

Release Date 2026-02-18

Last Version Date 2026-02-18

Entry Detail

PDB ID:

9J5L

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Complex structure of influenza hemagglutinin HA stem with CR9114 Fab and FISW84 Fab

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.97 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Designed influenza hemaggluti
Chain IDs:G (auth: 1), H
Chain Length:61
Number of Molecules:2
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:Designed influenza hemaggluti
Chain IDs:A (auth: 2), F (auth: J)
Chain Length:195
Number of Molecules:2
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:CR9114 light chain
Chain IDs:B
Chain Length:216
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:CR9114 heavy chain
Chain IDs:C
Chain Length:451
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:FISW84 light chain
Chain IDs:D
Chain Length:215
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:FISW84 heavy chain
Chain IDs:E
Chain Length:446
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

NAG

Primary Citation

Structure-based design of a broadly protective influenza hemagglutinin stem immunogen

Ru, Y.X, Liu, D.J, Deng, L, Li, Y.W.Show

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