ISDA: 9IAZ

Deposition Date 2025-02-11

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9IAZ

Keywords:

SIGNALING PROTEIN

Title:

CryoEM structure of the Themis:Grb2 complex with bound ProMacrobody 256, local refinement

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Escherichia coli (Taxon ID: 562)

Expression System(s):

Homo sapiens, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.20 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Growth factor receptor-bound
Gene (Uniprot):GRB2
Chain IDs:A
Chain Length:224
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62993

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein THEMIS
Chain IDs:B
Chain Length:641
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8N1K5

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ProMacrobody 256
Gene (Uniprot):malE
Chain IDs:C
Chain Length:478
Number of Molecules:1
Biological Source:synthetic construct, Escherichia coli

UniProt ID:9IAZ,P0AEY0 EC:3.5.4.38

Ligand Molecules

Primary Citation

Themis and Grb2 form a constitutive structural hub in T cell receptor signalling

Clancy, D.M, Sanz-Sanjuan, A, Gilis, E, Tougaard, P, Velghe, I, Van Droogenbroeck, Y, Felix, J, Bloch, Y, Furones Cuadrado, A, Merceron, R, Schenck, S, Vandenabeele, P, Brunner, J.D, Taghon, T, Elewaut, D, Savvides, S.N.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

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