ISDA: 9I7X

Deposition Date 2025-02-03

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9I7X

Keywords:

IMMUNE SYSTEM

Title:

Cryo-EM structure of human IL-36gamma in complex with the IL-36R and IL-1RAcP ectodomains

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens, Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.27 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Interleukin-1 receptor access
Chain IDs:A
Chain Length:351
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Interleukin-36 gamma
Chain IDs:B
Chain Length:152
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Interleukin-1 receptor-like 2
Mutagens:C154S, C262S
Chain IDs:C
Chain Length:320
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

NAG

Primary Citation

Structural basis of pro-inflammatory signaling via the IL-36 receptor mediated by IL-36g and IL-37

Andries, J, Toul, M, Felix, J, Clancy, D.M, Savvides, S.N.Show

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Primary Citation of related structures

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