9I0C image
Deposition Date 2025-01-14
Release Date 2026-07-29
Last Version Date 2026-07-29
Entry Detail
PDB ID:
9I0C
Keywords:
LIGASE
Title:
E3 ubiquitin ligase CBL-B in complex with inhibitor
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.12 Å
R-Value Free:
0.25
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
P 21 21 21
9I0C validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase C
Gene (Uniprot):CBLB
Chain IDs:A
Chain Length:394
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13191 Pfam ID:PF02262, PF02761, PF02762, PF00097
Ligand Molecules
A1IZE
NA
ZN
Primary Citation
Inhibiting Ubiquitin ligases: A Case Study on the Discovery, Mechanism, and Optimization of Cbl-b Inhibitors
To be published ? ? ? (?)
Primary Citation of related structures
9I0C
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