ISDA: 9HYL

Deposition Date 2025-01-10

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

9HYL

Keywords:

OXIDOREDUCTASE

Title:

Crystal structure of Trypanosoma brucei trypanothione reductase (TbTR) bound to PROTAC-3

Biological Source:

Source Organism(s):

Trypanosoma brucei (Taxon ID: 5691)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.08 Å

R-Value Free:

0.22

R-Value Work:

0.17

R-Value Observed:

0.18

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Trypanothione reductase
Gene (Uniprot):Tb10.406.0520
Chain IDs:A, B, C, D
Chain Length:495
Number of Molecules:4
Biological Source:Trypanosoma brucei

UniProt ID:Q389T8 Pfam ID:PF07992, PF02852 EC:1.8.1.12

Ligand Molecules

A1IYD

DMS

FAD

IMD

PEG

Primary Citation

Unlocking Targeted Protein Degradation in Parasites: A Chemical Approach to Address Trypanothione Reductase in Leishmania infantum

Salerno, A, Exertier, C, Antonelli, L, Fiorillo, A, Pasieka, A, Ocello, R, Morea, V, Altomare, A, Uliassi, E, Milleli, A, Aldini, G, Di Muccio, T, Ilari, A, Bolognesi, M.L.Show

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Primary Citation of related structures

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