ISDA: 9H6Z

Deposition Date 2024-10-25

Release Date 2026-05-06

Last Version Date 2026-07-08

Entry Detail

PDB ID:

9H6Z

Keywords:

FLAVOPROTEIN

Title:

AetF, a single-component flavin-dependent tryptophan halogenase, in complex with tryptoline

Biological Source:

Source Organism(s):

Aetokthonos hydrillicola Thurmond2011 (Taxon ID: 2712845)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.87 Å

R-Value Free:

0.18

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 43

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:AetF
Gene (Uniprot):aetF
Chain IDs:A, B
Chain Length:663
Number of Molecules:2
Biological Source:Aetokthonos hydrillicola Thurmond2011

UniProt ID:A0A861B9Z9

Ligand Molecules

FAD

PEG

WYH

Primary Citation

Structural basis of regioselective double halogenation of the beta-carboline tryptoline by the single-component halogenase AetF.

Bork, S, Horstmeier, H.J, Scharkowski, B, Niemann, H.H.Show

Acta Crystallogr D Struct Biol 82 836 844 (2026)

PMID: 42329691 DOI: 10.1107/S2059798326005954

Primary Citation of related structures

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