ISDA: 9GRW

Deposition Date 2024-09-12

Release Date 2025-09-24

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9GRW

Keywords:

LYASE

Title:

Structure of Heparinase I from Bacteroides eggerthii in complex with calcium cofactor

Biological Source:

Source Organism(s):

Bacteroides eggerthii (Taxon ID: 28111)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.85 Å

R-Value Free:

0.24

R-Value Work:

0.21

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Heparin lyase I
Gene (Uniprot):HMPREF1016_01920
Chain IDs:A, B
Chain Length:382
Number of Molecules:2
Biological Source:Bacteroides eggerthii

UniProt ID:E5WZ15 Pfam ID:PF14099

Ligand Molecules

ACT

SO4

Primary Citation

Enzymatic access to the rare Delta UA (1 - 4) Glc 3, 6, N-sulfated heparin disaccharide, implications for heparin quality control

Kandola, T.K, Mycroft-West, C.J, Andrade De Lima, M.L, Turner, A, Gardini, C, Urso, E, Miller, G, Bisio, A, Yates, E.A, Guerrini, M, Wu, L, Skidmore, M.A.Show

Biorxiv ? ? ? (2024)

DOI: 10.1101/2024.09.26.615151

Primary Citation of related structures

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