ISDA: 9G6Y

Deposition Date 2024-07-19

Release Date 2026-02-04

Last Version Date 2026-08-19

Entry Detail

PDB ID:

9G6Y

Keywords:

HYDROLASE

Title:

Crystal structure of NUDT5 bound to dNUDT5

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.90 Å

R-Value Free:

0.24

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:ADP-sugar pyrophosphatase
Gene (Uniprot):NUDT5
Chain IDs:A, B
Chain Length:0
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9UKK9 Pfam ID:PF00293 EC:2.7.7.96

Ligand Molecules

A1IIY

Primary Citation

Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response

Marques, A.S.M.C, Bauer, L.G, Nguyen, T.A, Orta, A.G, Venne, J.L, Cheng, C, Balikci, E, Liu, Y, Tivon, B, Kroupova, A, Ciulli, A, London, N, Kubicek, S, Huber, K.V.M.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-74489-9

Primary Citation of related structures

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