ISDA: 9FUF

Deposition Date 2024-06-26

Release Date 2026-01-14

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9FUF

Keywords:

TRANSFERASE

Title:

Crystal structure of human DYRK1A in complex with ARN25641

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.70 Å

R-Value Free:

0.23

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 42

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dual specificity tyrosine-pho
Gene (Uniprot):DYRK1A
Chain IDs:A
Chain Length:361
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13627 Pfam ID:PF00069 EC:2.7.12.1

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
PTR	A	TYR	modified residue

Ligand Molecules

A1IFO

Primary Citation

A Polypharmacology-Driven Approach to Alzheimer's Disease and Tauopathies: Rational Design, Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3 beta /FYN-alpha /DYRK1A) Inhibitors.

Demuro, S, Russo, D, Penna, I, Grabska, S, Grabski, H, Dalle Vedove, A, Valeri, A, Sauvey, C, Ottonello, G, Summa, M, Bertozzi, S.M, Ortega, J, Bertorelli, R, Storici, P, Girotto, S, Cruciani, G, Di Martino, R.M.C, Abagyan, R, Cavalli, A.Show

J.Med.Chem. 69 9991 10018 (2026)

PMID: 42054438 DOI: 10.1021/acs.jmedchem.5c01810

Primary Citation of related structures

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