ISDA: 9FUF

Deposition Date 2024-06-26

Release Date 2026-01-14

Last Version Date 2026-01-14

Entry Detail

PDB ID:

9FUF

Keywords:

TRANSFERASE

Title:

Crystal structure of human DYRK1A in complex with ARN25641

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.70 Å

R-Value Free:

0.23

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 42

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dual specificity tyrosine-pho
Gene (Uniprot):DYRK1A
Chain IDs:A
Chain Length:361
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13627 Pfam ID:PF00069 EC:2.7.12.1

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
PTR	A	TYR	modified residue

Ligand Molecules

A1IFO

Primary Citation

Unveiling the pharmacophoric traits of balanced triple GSK-3B/FYN/DYRK1A inhibitors: rational design and synthesis of novel amino-pyrazole containing scaffolds for the treatment of Alzheimer's disease and related tauopathies.

Demuro, S.Show

To be published ? ? ? (?)

Primary Citation of related structures

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