ISDA: 9FR8

Deposition Date 2024-06-18

Release Date 2026-01-14

Last Version Date 2026-07-29

Entry Detail

PDB ID:

9FR8

Keywords:

TRANSFERASE

Title:

Crystal structure of human GSK3B in complex with ARN25565

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.22

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Glycogen synthase kinase-3 be
Gene (Uniprot):GSK3B
Chain IDs:A, B
Chain Length:442
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P49841 Pfam ID:PF00069 EC:2.7.11.26

Ligand Molecules

A1IE7

Primary Citation

A Polypharmacology-Driven Approach to Alzheimer's Disease and Tauopathies: Rational Design, Synthesis and Characterization of Amino-Pyrazole-Based Multikinase (GSK-3 beta /FYN-alpha /DYRK1A) Inhibitors.

Demuro, S, Russo, D, Penna, I, Grabska, S, Grabski, H, Dalle Vedove, A, Valeri, A, Sauvey, C, Ottonello, G, Summa, M, Bertozzi, S.M, Ortega, J, Bertorelli, R, Storici, P, Girotto, S, Cruciani, G, Di Martino, R.M.C, Abagyan, R, Cavalli, A.Show

J.Med.Chem. 69 9991 10018 (2026)

PMID: 42054438 DOI: 10.1021/acs.jmedchem.5c01810

Primary Citation of related structures

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