9EZ9 image
Deposition Date 2024-04-11
Release Date 2025-07-23
Last Version Date 2026-08-12
Entry Detail
PDB ID:
9EZ9
Keywords:
OXIDOREDUCTASE
Title:
Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor N-(3'-(2,2-difluoropropoxy)-2,3,5,6-tetrafluoro-[1,1'-biphenyl]-4-yl)-2-hydroxypyrazolo[1,5-a]pyridine-3-carboxamide
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.60 Å
R-Value Free:
0.23
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 32 2 1
9EZ9 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dihydroorotate dehydrogenase
Gene (Uniprot):DHODH
Chain IDs:A
Chain Length:390
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q02127 Pfam ID:PF01180 EC:1.3.5.2
Ligand Molecules
A1H8I
FMN
ORO
P6G
SO4
Primary Citation
Targeting dihydroorotate dehydrogenase (hDHODH) beyond the barrier: discovery of MEDS700 as blood-brain barrier permeable hDHODH inhibitor.
Eur.J.Med.Chem. 314 118896 118896 (2026)
PMID: 42119261 DOI: 10.1016/j.ejmech.2026.118896
Primary Citation of related structures
9EZ9
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