ISDA: 9EK5

Deposition Date 2024-11-30

Release Date 2025-08-27

Last Version Date 2026-03-11

Entry Detail

PDB ID:

9EK5

Keywords:

IMMUNE SYSTEM

Title:

TRIM21 PrySpry domain bound to an enhanced PRLX-93936 analog

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.10 Å

R-Value Free:

0.26

R-Value Work:

0.19

Space Group:

P 41 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase T
Gene (Uniprot):TRIM21
Chain IDs:A
Chain Length:181
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P19474 Pfam ID:PF13765, PF00622

Ligand Molecules

A1BLD

Primary Citation

Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex.

Yuan, L, Ji, W, Dwyer, B.G, Lu, J, Bian, J, Colombo, G.M, Martinez, M.J, Fernandez, D, Phillips, N.A, Tang, M.T, Zhou, C.W, Quispe Calla, N.E, Guzman Huancas, C, Eckart, M, Tran, J, Jones, H.M, Qiu, T, Doench, J.G, Rees, M.G, Roth, J.A, Cameron, M.D, Charville, G.W, Kuo, C.J, Dixon, S.J, Zhang, T, Hinshaw, S.M, Gray, N.S, Corsello, S.M.Show

Cancer Discov 15 2505 2529 (2025)

PMID: 40891634 DOI: 10.1158/2159-8290.CD-25-0271

Primary Citation of related structures

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