ISDA: 9EDZ

Deposition Date 2024-11-18

Release Date 2026-03-18

Last Version Date 2026-09-30

Entry Detail

PDB ID:

9EDZ

Keywords:

VIRAL PROTEIN

Title:

HIV CA - GLFG peptide (4 mM)

Biological Source:

Source Organism(s):

Human immunodeficiency virus type 1 (Taxon ID: 11698)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.00 Å

R-Value Free:

0.26

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Capsid protein p24
Gene (Uniprot):gag
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L
Chain Length:0
Number of Molecules:12
Biological Source:Human immunodeficiency virus type 1

UniProt ID:P12493

Polymer Type:polypeptide(L)
Molecule:GLFG peptide
Chain IDs:M (auth: N), N (auth: O), O (auth: P), P (auth: R), Q (auth: S), R (auth: V), S (auth: W), T (auth: M), U (auth: Q), V (auth: U), W (auth: X)
Chain Length:0
Number of Molecules:11
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient.

Melcak, I, Slack, R.L, Lorson, Z.C, Emanuelli Castaner, A, Ambrus, K, Winkjer, J.S, Kirby, K.A, Dick, R.A, Sarafianos, S.G.Show

Proc.Natl.Acad.Sci.USA 123 e2534919123 e2534919123 (2026)

PMID: 42412942 DOI: 10.1073/pnas.2534919123

Primary Citation of related structures

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