ISDA: 9DNO

Deposition Date 2024-09-17

Release Date 2025-08-13

Last Version Date 2026-02-25

Entry Detail

PDB ID:

9DNO

Keywords:

PROTEIN BINDING

Title:

Structure of UBR1-RFF complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.33 Å

R-Value Free:

0.20

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:E3 ubiquitin-protein ligase U
Gene (Uniprot):UBR1
Chain IDs:A, B
Chain Length:77
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q8IWV7 Pfam ID:PF02207 EC:3.4.17.20

Polymer Type:polypeptide(L)
Molecule:ARG-PHE-PHE-NH2
Chain IDs:C (auth: D), D (auth: E)
Chain Length:4
Number of Molecules:2
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

An alternative pocket for binding the N-degrons by the UBR1 and UBR2 ubiquitin E3 ligases.

Huang, S.T, Chen, D.H, Ren, T, Thomas, N, Wu, J, Sankaran, B, Jones, R, Taylor, S, Chen, Y.Show

Protein Sci. 34 e70248 e70248 (2025)

PMID: 40880185 DOI: 10.1002/pro.70248

Primary Citation of related structures

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