9CX9 image
Deposition Date 2024-07-31
Release Date 2024-11-13
Last Version Date 2026-04-08
Entry Detail
PDB ID:
9CX9
Title:
Structure of SH3 domain of Src in complex with beta-arrestin 1
Biological Source:
Source Organism(s):
Mus musculus (Taxon ID: 10090)
Rattus norvegicus (Taxon ID: 10116)
Gallus gallus (Taxon ID: 9031)
Homo sapiens (Taxon ID: 9606)
Method Details:
Experimental Method:
Resolution:
3.34 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Beta-arrestin-1
Gene (Uniprot):Arrb1
Mutagens:C59V, E92C, C125S, C140L, C150V, C242V, C251V, C269S
Chain IDs:D (auth: A)
Chain Length:392
Number of Molecules:1
Biological Source:Rattus norvegicus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proto-oncogene tyrosine-prote
Gene (Uniprot):SRC
Mutagens:R95C
Chain IDs:E (auth: B)
Chain Length:85
Number of Molecules:1
Biological Source:Gallus gallus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antibody fragment Fab30, heav
Chain IDs:A (auth: H)
Chain Length:237
Number of Molecules:1
Biological Source:Mus musculus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Antibody fragment Fab30, ligh
Chain IDs:B (auth: L)
Chain Length:215
Number of Molecules:1
Biological Source:Mus musculus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Vasopressin V2 receptor
Gene (Uniprot):AVPR2
Chain IDs:C (auth: V)
Chain Length:29
Number of Molecules:1
Biological Source:Homo sapiens
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
SEP C SER modified residue
TPO C THR modified residue
Ligand Molecules
Primary Citation
Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.
Nat Commun 17 ? ? (2026)
PMID: 41720803 DOI: 10.1038/s41467-026-69884-1
Primary Citation of related structures
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