ISDA: 9CSM

Deposition Date 2024-07-24

Release Date 2025-07-30

Last Version Date 2026-08-12

Entry Detail

PDB ID:

9CSM

Keywords:

HYDROLASE

Title:

Crystal structure of human ribonuclease 7 (RNase 7, HsR7)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.77 Å

R-Value Free:

0.21

R-Value Work:

0.17

R-Value Observed:

0.18

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribonuclease 7
Gene (Uniprot):RNASE7
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9H1E1 Pfam ID:PF00074 EC:3.1.27.-

Ligand Molecules

EDO

MES

MPD

PEG

Primary Citation

Engineering human RNase 7 with an eosinophil RNase segment reveals determinants of cytotoxic and antimicrobial activity.

Tran, T.T.Q, Larda, S.T, Nieves, C, Veyrier, F.J, Calmettes, C, Doucet, N.Show

J.Biol.Chem. 302 113189 113189 (2026)

PMID: 42203172 DOI: 10.1016/j.jbc.2026.113189

Primary Citation of related structures

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