8YFO image
Deposition Date 2024-02-25
Release Date 2025-09-03
Last Version Date 2026-09-02
Entry Detail
PDB ID:
8YFO
Keywords:
MEMBRANE PROTEIN
Title:
A cryo-EM structure of Ac-LA-PTH-PTH1R-Gs complex
Biological Source:
Source Organism(s):
Bos taurus (Taxon ID: 9913)
Rattus norvegicus (Taxon ID: 10116)
Lama glama (Taxon ID: 9844)
Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.71 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
8YFO validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:A
Chain Length:361
Number of Molecules:1
Biological Source:Bos taurus
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:B
Chain Length:370
Number of Molecules:1
Biological Source:Rattus norvegicus
UniProt ID:P62873 Pfam ID:PF00400, PF25391
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:C (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:P59768 Pfam ID:PF00631
Polymer Type:polypeptide(L)
Molecule:NB35
Chain IDs:D (auth: N)
Chain Length:133
Number of Molecules:1
Biological Source:Lama glama
Polymer Type:polypeptide(L)
Molecule:Ac-LA-PTH
Chain IDs:E (auth: P)
Chain Length:33
Number of Molecules:1
Biological Source:synthetic construct
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Parathyroid hormone/parathyro
Gene (Uniprot):PTH1R
Chain IDs:F (auth: R)
Chain Length:476
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q03431 Pfam ID:PF02793, PF00002
Ligand Molecules
NA
Primary Citation
Structural basis of PTH1R-beta-arrestin core engagement reveals design principles for G-protein-biased therapeutics.
Nat.Struct.Mol.Biol. 33 868 881 (2026)
PMID: 42115346 DOI: 10.1038/s41594-026-01806-7
Primary Citation of related structures
8YFO
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