ISDA: 8XTU

Deposition Date 2024-01-11

Release Date 2025-01-15

Last Version Date 2026-07-29

Entry Detail

PDB ID:

8XTU

Keywords:

ENDOCYTOSIS

Title:

Crystal Structure of Rab5b GTPase domain from Leishmania donovani in complex with GDP

Biological Source:

Source Organism(s):

Leishmania donovani (Taxon ID: 5661)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.22

Space Group:

P 2 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Rab5
Mutagens:C62S, Q80L, C151S
Chain IDs:A
Chain Length:168
Number of Molecules:1
Biological Source:Leishmania donovani

UniProt ID:Q6VN21 Pfam ID:PF00071

Ligand Molecules

GDP

Primary Citation

Analysis of structure and stability of Leishmania donovani Rab5a and Rab5b.

Pandey, D, Zohib, M, Chaurasia, A, Ansari, H, Chowdhury, A, Pal, R.K, Tripathi, S, Jain, A, Biswal, B.K, Siddiqi, M.I, Arora, A.Show

Int.J.Biol.Macromol. 365 152349 152349 (2026)

PMID: 42070609 DOI: 10.1016/j.ijbiomac.2026.152349

Primary Citation of related structures

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