8UGO image
Deposition Date 2023-10-05
Release Date 2025-07-09
Last Version Date 2026-03-04
Entry Detail
PDB ID:
8UGO
Title:
Structure of the complex between Human LIAS and H-protein in the presence of 5'-deoxyadenosine
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
2.45 Å
R-Value Free:
0.22
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
P 21 21 21
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Lipoyl synthase, mitochondria
Gene (Uniprot):LIAS
Chain IDs:A, C (auth: B), E (auth: D)
Chain Length:368
Number of Molecules:3
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Glycine cleavage system H pro
Gene (Uniprot):GCSH
Chain IDs:B (auth: E), D (auth: C), F
Chain Length:173
Number of Molecules:3
Biological Source:Homo sapiens
Primary Citation
Structural basis for catalysis by human lipoyl synthase.
Nat Commun 16 6355 6355 (2025)
PMID: 40640146 DOI: 10.1038/s41467-025-61393-x
Primary Citation of related structures
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