8TT9 image
Deposition Date 2023-08-13
Release Date 2024-08-28
Last Version Date 2026-09-09
Entry Detail
PDB ID:
8TT9
Keywords:
CYTOKINE
Title:
X-ray structure of Macrophage Migration Inhibitory Factor (MIF) Covalently Bound to 4-hydroxyphenylpyruvate (HPP)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.68 Å
R-Value Free:
0.19
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 21 21 21
8TT9 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Macrophage migration inhibito
Gene (Uniprot):MIF
Chain IDs:A, B, C
Chain Length:114
Number of Molecules:3
Biological Source:Homo sapiens
UniProt ID:P14174 Pfam ID:PF01187 EC:5.3.2.1
Ligand Molecules
ENO
IPA
Primary Citation
Identification of a key water molecule involved in the macrophage migration inhibitory factor-catalyzed tautomerization of para-hydroxyphenylpyruvate using neutron crystallography.
Protein Sci. 35 e70666 e70666 (2026)
PMID: 42568349 DOI: 10.1002/pro.70666
Primary Citation of related structures
8TT9
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