8TM9 image
Deposition Date 2023-07-28
Release Date 2024-12-11
Last Version Date 2026-07-08
Entry Detail
PDB ID:
8TM9
Keywords:
DE NOVO PROTEIN
Title:
Computationally designed tunable C2 symmetric tandem repeat homodimer, D_3_633_8x bound to peptide
Biological Source:
Source Organism(s):
synthetic construct (Taxon ID: 32630)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.05 Å
R-Value Free:
0.24
R-Value Work:
0.20
R-Value Observed:
0.21
Space Group:
P 1 21 1
8TM9 validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:D_3_633_8x peptide bound
Chain IDs:A, B
Chain Length:234
Number of Molecules:2
Biological Source:synthetic construct
Structural Superimposition Protein Blast
Polymer Type:polypeptide(D)
Molecule:MC1
Chain IDs:C (auth: D)
Chain Length:8
Number of Molecules:1
Biological Source:synthetic construct
Ligand Molecules
POL
SO4
Primary Citation
De novo design of a macrocycle-induced dimerization system for cellular control.
Nat Commun ? ? ? (2026)
PMID: 42151133 DOI: 10.1038/s41467-026-71345-8
Primary Citation of related structures
8TM9
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