ISDA: 8TLP

Deposition Date 2023-07-27

Release Date 2024-12-11

Last Version Date 2026-07-08

Entry Detail

PDB ID:

8TLP

Keywords:

DE NOVO PROTEIN

Title:

Computationally designed tunable C2 symmetric tandem repeat homodimer, D_3_633_8x without peptide

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.28

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:D_3_633_8x, no peptide
Chain IDs:A, B
Chain Length:252
Number of Molecules:2
Biological Source:synthetic construct

Ligand Molecules

SO4

Primary Citation

De novo design of a macrocycle-induced dimerization system for cellular control.

Hanna, S, Salveson, P.J, Wicky, B, Kennedy, M.A, Hicks, D.R, Moller, C, Cheng, S, Li, X, Abedi, M, Coventry, B, Said, M.Y, Bera, A.K, Kang, A, Stoddard, B.L, Baker, D.Show

Nat Commun ? ? ? (2026)

PMID: 42151133 DOI: 10.1038/s41467-026-71345-8

Primary Citation of related structures

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