ISDA: 8EVN

Deposition Date 2022-10-20

Release Date 2023-10-25

Last Version Date 2026-03-18

Entry Detail

PDB ID:

8EVN

Keywords:

OXIDOREDUCTASE/INHIBITOR

Title:

Sulfatase from Mycobacterium tuberculosis (Rv3406) in complex with N-oxalylglycine (NOG)

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis (Taxon ID: 1773)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.64 Å

R-Value Free:

0.29

R-Value Work:

0.25

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alpha-ketoglutarate-dependent
Gene (Uniprot):MTCY78.22c
Chain IDs:A, B, C, D
Chain Length:298
Number of Molecules:4
Biological Source:Mycobacterium tuberculosis

UniProt ID:P9WKZ1 Pfam ID:PF02668 EC:1.14.11.77

Ligand Molecules

OGA

TRS

Primary Citation

Structural remodelling of the 2OG oxygenase Rv3406 enables sulfur-scavenging in Mycobacterium tuberculosis.

Juan, V.T, Bajan, P, Eurtivong, C, Liu, T, Squire, C.J, Huang, E.Y, Leung, I.K.H.Show

Chem.Commun.(Camb.) 61 19020 19023 (2025)

PMID: 41178574 DOI: 10.1039/d5cc05573c

Primary Citation of related structures

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