8BQS image
Deposition Date 2022-11-21
Release Date 2023-08-23
Last Version Date 2026-09-16
Entry Detail
PDB ID:
8BQS
Title:
Cryo-EM structure of the I-II-III2-IV2 respiratory supercomplex from Tetrahymena thermophila
Biological Source:
Source Organism(s):
Method Details:
Experimental Method:
Resolution:
2.90 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Peptidase M16 inactive domain
Gene (Uniprot):TTHERM_00502380
Chain IDs:GC (auth: A), SC (auth: a)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Lipid-A-disaccharide synthase
Gene (Uniprot):TTHERM_00925340
Chain IDs:A (auth: A0)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NAD-dependent epimerase/dehyd
Gene (Uniprot):TTHERM_00557760
Chain IDs:B (auth: A1)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:DnaJ domain protein
Gene (Uniprot):TTHERM_00938750
Chain IDs:C (auth: A2)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Acyl-CoA synthetase (AMP-form
Gene (Uniprot):TTHERM_01000190
Chain IDs:D (auth: A3)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:RNase III domain-containing p
Gene (Uniprot):TTHERM_00268000
Chain IDs:E (auth: A4)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:37S ribosomal protein S25, mi
Gene (Uniprot):TTHERM_00399360
Chain IDs:F (auth: A5)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00697370
Chain IDs:G (auth: A6)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:CX9C domain-containing protei
Gene (Uniprot):TTHERM_00464930
Chain IDs:H (auth: A7)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:ND5a
Chain IDs:I (auth: A8)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00945210
Chain IDs:J (auth: A9)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase subunit 5
Gene (Uniprot):nad5
Chain IDs:K (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):TTHERM_00194260
Chain IDs:L (auth: AB)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):nad4
Chain IDs:M (auth: AC)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):TTHERM_00193910
Chain IDs:N (auth: AD)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase subunit 7
Gene (Uniprot):nad7
Chain IDs:O (auth: AE)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ymf65
Gene (Uniprot):ymf65
Chain IDs:P (auth: AF)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transcription factor apfi pro
Gene (Uniprot):TTHERM_00136440
Chain IDs:Q (auth: AG)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):nad1_a
Chain IDs:R (auth: AH)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):TTHERM_00335630
Chain IDs:S (auth: AI)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ymf62
Gene (Uniprot):ymf62
Chain IDs:T (auth: AJ)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Gamma-carbonic anhydrase
Gene (Uniprot):TTHERM_01005010
Chain IDs:U (auth: AK)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):TTHERM_00294640
Chain IDs:V (auth: AL)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Gamma-carbonic anhydrase
Gene (Uniprot):TTHERM_00541460
Chain IDs:W (auth: AM)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:ETC complex I subunit motif p
Gene (Uniprot):TTHERM_01161000
Chain IDs:X (auth: AN)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase subunit 9
Gene (Uniprot):nad9_2
Chain IDs:Y (auth: AO)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):TTHERM_00194499
Chain IDs:Z (auth: AP)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):TTHERM_00985010
Chain IDs:AA (auth: AQ)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):TTHERM_00526930
Chain IDs:BA (auth: AR)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase, putative
Gene (Uniprot):TTHERM_00933070
Chain IDs:CA (auth: AS)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase subunit 10
Gene (Uniprot):nad10
Chain IDs:DA (auth: AT)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):TTHERM_00715850
Chain IDs:EA (auth: AU)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Acyl carrier protein
Gene (Uniprot):TTHERM_01005100
Chain IDs:FA (auth: AV)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Acyl carrier protein
Gene (Uniprot):TTHERM_00470710
Chain IDs:GA (auth: AW)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH-ubiquinone oxidoreductas
Gene (Uniprot):nad3
Chain IDs:HA (auth: AX)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ymf58
Gene (Uniprot):ymf58
Chain IDs:IA (auth: AY)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L51/S25/CI-
Gene (Uniprot):TTHERM_00659070
Chain IDs:JA (auth: AZ)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:M16 family peptidase, putativ
Gene (Uniprot):TTHERM_00836690
Chain IDs:HC (auth: B), TC (auth: b)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00455560
Chain IDs:KA (auth: B0)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:ATP synthase subunit e, mitoc
Gene (Uniprot):TTHERM_00835330
Chain IDs:LA (auth: B1)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:GRAM domain protein
Gene (Uniprot):TTHERM_000129647
Chain IDs:MA (auth: B2)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00446569
Chain IDs:NA (auth: B3)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00992800
Chain IDs:OA (auth: B4)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00399460
Chain IDs:PA (auth: B5)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase subunit 1
Gene (Uniprot):nad1_b
Chain IDs:QA (auth: B6)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein
Gene (Uniprot):TTHERM_00295430
Chain IDs:RA (auth: BA)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00114380
Chain IDs:SA (auth: BB)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NDUB8
Gene (Uniprot):TTHERM_00481330
Chain IDs:TA (auth: BC)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00649080
Chain IDs:UA (auth: BD)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NDUPH2
Gene (Uniprot):TTHERM_00193950
Chain IDs:VA (auth: BE)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NDUB10
Gene (Uniprot):TTHERM_00193750
Chain IDs:WA (auth: BF)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NDUA13
Gene (Uniprot):TTHERM_00149260
Chain IDs:XA (auth: BG)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase subunit 2
Gene (Uniprot):nad2
Chain IDs:YA (auth: BH)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:2 iron, 2 sulfur cluster-bind
Gene (Uniprot):TTHERM_00161210
Chain IDs:ZA (auth: BI)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Thioredoxin
Gene (Uniprot):TTHERM_01205250
Chain IDs:AB (auth: BJ)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:COX assembly mitochondrial pr
Gene (Uniprot):TTHERM_00334340
Chain IDs:BB (auth: BK)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00637590
Chain IDs:CB (auth: BL)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00148710
Chain IDs:DB (auth: BM)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:PH domain-containing protein
Gene (Uniprot):TTHERM_00006120
Chain IDs:EB (auth: BN)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):TTHERM_00653670
Chain IDs:FB (auth: BO)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NDUB6
Gene (Uniprot):TTHERM_00430000
Chain IDs:GB (auth: BP)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):TTHERM_00616320
Chain IDs:HB (auth: BQ)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Zinc-finger protein
Gene (Uniprot):TTHERM_00497570
Chain IDs:IB (auth: BR)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NDUB4
Gene (Uniprot):TTHERM_00310880
Chain IDs:JB (auth: BS)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NDUTT10
Chain IDs:KB (auth: BT)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NDUTT11
Chain IDs:LB (auth: BU)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NDUTT12
Chain IDs:MB (auth: BV)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:CHCH domain-containing protei
Gene (Uniprot):TTHERM_00402070
Chain IDs:NB (auth: BW)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00185570
Chain IDs:OB (auth: BX)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ymf57
Gene (Uniprot):ymf57
Chain IDs:PB (auth: BY)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Complex I-MNLL
Gene (Uniprot):TTHERM_00160690
Chain IDs:QB (auth: BZ)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Apocytochrome b
Gene (Uniprot):cob
Chain IDs:IC (auth: C), UC (auth: c)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Succinate dehydrogenase [ubiq
Gene (Uniprot):TTHERM_00047080
Chain IDs:UB (auth: CA)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:succinate dehydrogenase
Gene (Uniprot):TTHERM_00241700
Chain IDs:WB (auth: CB)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein
Gene (Uniprot):TTHERM_00387120
Chain IDs:DC (auth: CC)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:succinate dehydrogenase compl
Chain IDs:FC (auth: CD)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NmrA domain-containing protei
Gene (Uniprot):TTHERM_00571650
Chain IDs:AC (auth: CE)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00532090
Chain IDs:XB (auth: CF)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:chain 77
Gene (Uniprot):TTHERM_00283850
Chain IDs:YB (auth: CG)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Diphthamide synthesis protein
Gene (Uniprot):TTHERM_00658950
Chain IDs:RB (auth: CH)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:DUF4885 domain-containing pro
Gene (Uniprot):TTHERM_00601860
Chain IDs:VB (auth: CI)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00626980
Chain IDs:BC (auth: CJ)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00713350
Chain IDs:ZB (auth: CK)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transposase
Gene (Uniprot):TTHERM_000287919
Chain IDs:TB (auth: CL)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00637670
Chain IDs:SB (auth: CM)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_001034353
Chain IDs:CC (auth: CN)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:SDHTT11
Chain IDs:EC (auth: CO)
Chain Length:0
Number of Molecules:1
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Cytochrome protein c1
Gene (Uniprot):TTHERM_00918500
Chain IDs:JC (auth: D), VC (auth: d)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):cox1
Chain IDs:ED (auth: DA), EF (auth: Da)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):cox2
Chain IDs:FD (auth: DB), FF (auth: Db)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ymf68
Gene (Uniprot):ymf68
Chain IDs:GD (auth: DC), GF (auth: Dc)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Cytochrome C oxidase subunit
Gene (Uniprot):TTHERM_00378620
Chain IDs:HD (auth: DD), HF (auth: Dd)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_000723218
Chain IDs:ID (auth: DE), IF (auth: De)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Structural protein
Gene (Uniprot):TTHERM_00568030
Chain IDs:JD (auth: DF), JF (auth: Df)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00046170
Chain IDs:KD (auth: DG), KF (auth: Dg)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00151250
Chain IDs:LD (auth: DH), LF (auth: Dh)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):TTHERM_000470561
Chain IDs:MD (auth: DI), MF (auth: Di)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_001001528
Chain IDs:ND (auth: DJ), NF (auth: Dj)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:CTF/NF-I domain-containing pr
Gene (Uniprot):TTHERM_01043280
Chain IDs:OD (auth: DK), OF (auth: Dk)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00361490
Chain IDs:PD (auth: DM), PF (auth: Dm)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ymf67
Gene (Uniprot):ymf67
Chain IDs:QD (auth: DN), QF (auth: Dn)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Protein phosphatase 2C, putat
Gene (Uniprot):TTHERM_00721790
Chain IDs:RD (auth: DO), RF (auth: Do)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:SURF1-like protein
Gene (Uniprot):TTHERM_00338280
Chain IDs:SD (auth: DP), SF (auth: Dp)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:TraB family protein
Gene (Uniprot):TTHERM_00046440
Chain IDs:TD (auth: DQ), TF (auth: Dq)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00047230
Chain IDs:UD (auth: DR), UF (auth: Dr)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Oxoglutarate/malate transloca
Gene (Uniprot):TTHERM_00127269
Chain IDs:VD (auth: DS), VF (auth: Ds)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:NADH dehydrogenase [ubiquinon
Gene (Uniprot):TTHERM_00675650
Chain IDs:WD (auth: DT), WF (auth: Dt)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Carrier protein
Gene (Uniprot):TTHERM_00112650
Chain IDs:XD (auth: DU), XF (auth: Du)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:2-oxoglutarate/malate carrier
Gene (Uniprot):TTHERM_00621600
Chain IDs:YD (auth: DV), YF (auth: Dv)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:SURF1-like protein
Gene (Uniprot):TTHERM_00070850
Chain IDs:ZD (auth: DW), ZF (auth: Dw)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:COXTT9
Gene (Uniprot):TTHERM_00525160
Chain IDs:AE (auth: DX), AG (auth: Dx)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:COXTT10
Gene (Uniprot):TTHERM_00420130
Chain IDs:BE (auth: DY), BG (auth: Dy)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L9, mit
Gene (Uniprot):TTHERM_000939159
Chain IDs:CE (auth: DZ), CG (auth: Dz)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Chromosome condensation regul
Gene (Uniprot):TTHERM_00016360
Chain IDs:EH (auth: Dl), FH (auth: DL)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Rieske iron-sulfur protein, u
Gene (Uniprot):TTHERM_00295080
Chain IDs:KC (auth: E), WC (auth: e)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:COXTT12,Transmembrane protein
Gene (Uniprot):TTHERM_00455090
Chain IDs:DE (auth: EA), DG (auth: Ea)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00530650
Chain IDs:EE (auth: EB), EG (auth: Eb)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:COXTT27
Chain IDs:FE (auth: EC), FG (auth: Ec)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ymf75
Gene (Uniprot):ymf75
Chain IDs:GE (auth: ED), GG (auth: Ed)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Mobilization protein
Gene (Uniprot):TTHERM_00641250
Chain IDs:HE (auth: EE), HG (auth: Ee)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Iron-binding zinc finger CDGS
Gene (Uniprot):TTHERM_00133510
Chain IDs:IE (auth: EF), IG (auth: Ef)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:COXTT28
Chain IDs:JE (auth: EG), JG (auth: Eg)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00049040
Chain IDs:KE (auth: EH), KG (auth: Eh)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein
Gene (Uniprot):TTHERM_00218570
Chain IDs:LE (auth: EI), LG (auth: Ei)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:YflT domain-containing protei
Gene (Uniprot):TTHERM_00218840
Chain IDs:YE (auth: EJ), YG (auth: Ej)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Complex III subunit VII
Gene (Uniprot):TTHERM_00433830
Chain IDs:NE (auth: EK), NG (auth: Ek)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00794470
Chain IDs:OE (auth: EL), OG (auth: El)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00938940
Chain IDs:PE (auth: EM), PG (auth: Em)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:COXTT22
Gene (Uniprot):TTHERM_00691100
Chain IDs:QE (auth: EN), QG (auth: En)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00666370
Chain IDs:RE (auth: EO), RG (auth: Eo)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Phage protein
Gene (Uniprot):TTHERM_00695750
Chain IDs:SE (auth: EP), SG (auth: Ep)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00161000
Chain IDs:TE (auth: EQ), TG (auth: Eq)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Lysozyme
Gene (Uniprot):TTHERM_00151580
Chain IDs:UE (auth: ER), UG (auth: Er)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ymf70
Gene (Uniprot):ymf70
Chain IDs:VE (auth: ES), VG (auth: Es)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Zf-Tim10_DDP domain-containin
Gene (Uniprot):TTHERM_00433490
Chain IDs:WE (auth: ET), WG (auth: Et)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:ABC transporter
Gene (Uniprot):TTHERM_00485790
Chain IDs:XE (auth: EU), XG (auth: Eu)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Decapping nuclease
Gene (Uniprot):TTHERM_00218340
Chain IDs:ME (auth: EV), MG (auth: Ev)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Cullin domain-containing prot
Gene (Uniprot):TTHERM_00028510
Chain IDs:ZE (auth: EW), ZG (auth: Ew)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Zf-Tim10_DDP domain-containin
Gene (Uniprot):TTHERM_000703379
Chain IDs:AF (auth: EX), AH (auth: Ex)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Annexin
Gene (Uniprot):TTHERM_00805850
Chain IDs:BF (auth: EY), BH (auth: Ey)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transposase
Gene (Uniprot):TTHERM_01289060
Chain IDs:CF (auth: EZ), CH (auth: Ez)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Ubiquinol-cytochrome C reduct
Gene (Uniprot):TTHERM_00194690
Chain IDs:LC (auth: F), XC (auth: f)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Tim10/DDP family zinc finger
Gene (Uniprot):TTHERM_000528460
Chain IDs:DF (auth: FA), DH (auth: Fa)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:UQCRTT1
Gene (Uniprot):TTHERM_00382330
Chain IDs:MC (auth: G), YC (auth: g)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00765330
Chain IDs:NC (auth: H), ZC (auth: h)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00456790
Chain IDs:OC (auth: I), AD (auth: i)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:UQCRTT3
Chain IDs:PC (auth: J), DD (auth: j)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:Transmembrane protein, putati
Gene (Uniprot):TTHERM_00218930
Chain IDs:QC (auth: K), BD (auth: k)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Polymer Type:polypeptide(L)
Molecule:UQCRTT2
Chain IDs:RC (auth: L), CD (auth: l)
Chain Length:0
Number of Molecules:2
Biological Source:Tetrahymena thermophila SB210
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
AME LD MET modified residue
TPO HD THR modified residue
Primary Citation
Structural basis of mitochondrial membrane bending by the I-II-III 2 -IV 2 supercomplex.
Nature 615 934 938 (2023)
PMID: 36949187 DOI: 10.1038/s41586-023-05817-y

Abstact

Mitochondrial energy conversion requires an intricate architecture of the inner mitochondrial membrane1. Here we show that a supercomplex containing all four respiratory chain components contributes to membrane curvature induction in ciliates. We report cryo-electron microscopy and cryo-tomography structures of the supercomplex that comprises 150 different proteins and 311 bound lipids, forming a stable 5.8-MDa assembly. Owing to subunit acquisition and extension, complex I associates with a complex IV dimer, generating a wedge-shaped gap that serves as a binding site for complex II. Together with a tilted complex III dimer association, it results in a curved membrane region. Using molecular dynamics simulations, we demonstrate that the divergent supercomplex actively contributes to the membrane curvature induction and tubulation of cristae. Our findings highlight how the evolution of protein subunits of respiratory complexes has led to the I-II-III2-IV2 supercomplex that contributes to the shaping of the bioenergetic membrane, thereby enabling its functional specialization.

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Disease

Primary Citation of related structures
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