ISDA: 7YCO

Deposition Date 2022-07-01

Release Date 2023-07-05

Last Version Date 2026-09-09

Entry Detail

PDB ID:

7YCO

Keywords:

PROTEIN BINDING

Title:

Crystal structure of SARS-CoV-2 Receptor Binding Domain bound to A6 repebody

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)
Cyclostomatida (Taxon ID: 97265)

Expression System(s):

Spodoptera frugiperda, Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.96 Å

R-Value Free:

0.25

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

I 41

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Spike protein S1
Gene (Uniprot):S
Chain IDs:A
Chain Length:198
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTC2 Pfam ID:PF09408

Polymer Type:polypeptide(L)
Molecule:Repebody (A6)
Chain IDs:B
Chain Length:267
Number of Molecules:1
Biological Source:Cyclostomatida

Ligand Molecules

NAG

Primary Citation

A bivalent form of a RBD-specific synthetic antibody effectively neutralizes SARS-CoV-2 variants.

Kim, D.G, Kim, U, Park, I.H, Ryu, B, Yoo, Y, Cha, J.S, Yoon, G.Y, Kim, S.H, Oh, H, Seo, J.Y, Nam, K.T, Seong, J.K, Shin, J.S, Cho, H.S, Kim, H.S.Show

Antiviral Res. 220 105738 105738 (2023)

PMID: 37944822 DOI: 10.1016/j.antiviral.2023.105738

Primary Citation of related structures

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