ISDA: 7QI5

Deposition Date 2021-12-14

Release Date 2023-07-05

Last Version Date 2026-09-16

Entry Detail

PDB ID:

7QI5

Keywords:

RIBOSOME

Title:

Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.63 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L32, mi
Gene (Uniprot):MRPL32
Chain IDs:GB (auth: 0)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BYC8 Pfam ID:PF01783

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L33, mi
Gene (Uniprot):MRPL33
Chain IDs:HB (auth: 1)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O75394 Pfam ID:PF00471

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L34, mi
Gene (Uniprot):MRPL34
Chain IDs:IB (auth: 2)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BQ48 Pfam ID:PF00468

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L35, mi
Gene (Uniprot):MRPL35
Chain IDs:JB (auth: 3)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NZE8 Pfam ID:PF01632

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L36, mi
Gene (Uniprot):MRPL36
Chain IDs:KB (auth: 4)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9P0J6 Pfam ID:PF00444

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L37, mi
Gene (Uniprot):MRPL37
Chain IDs:LB (auth: 5)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BZE1 Pfam ID:PF07147

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L38, mi
Gene (Uniprot):MRPL38
Chain IDs:MB (auth: 6)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96DV4 Pfam ID:PF01161

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L39, mi
Gene (Uniprot):MRPL39
Chain IDs:NB (auth: 7)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NYK5

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L40, mi
Gene (Uniprot):MRPL40
Chain IDs:OB (auth: 8)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NQ50 Pfam ID:PF09812

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L41, mi
Gene (Uniprot):MRPL41
Chain IDs:PB (auth: 9)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8IXM3 Pfam ID:PF09809

Polymer Type:polyribonucleotide
Molecule:16S mitochondrial rRNA
Chain IDs:JA (auth: A)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S34, mi
Gene (Uniprot):MRPS34
Chain IDs:AA (auth: A0)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82930 Pfam ID:PF16053

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S35, mi
Gene (Uniprot):MRPS35
Chain IDs:BA (auth: A1)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82673 Pfam ID:PF10213

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Coiled-coil-helix-coiled-coil
Gene (Uniprot):CHCHD1
Chain IDs:CA (auth: A2)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96BP2 Pfam ID:PF06747

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Aurora kinase A-interacting p
Gene (Uniprot):AURKAIP1
Chain IDs:DA (auth: A3)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NWT8 Pfam ID:PF08213

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Pentatricopeptide repeat doma
Gene (Uniprot):PTCD3
Chain IDs:EA (auth: A4)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96EY7 Pfam ID:PF22330, PF13812

Polymer Type:polyribonucleotide
Molecule:12S mitochondrial rRNA
Chain IDs:A (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S2, mit
Gene (Uniprot):MRPS2
Chain IDs:B (auth: AB)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y399 Pfam ID:PF00318

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S24, mi
Gene (Uniprot):MRPS24
Chain IDs:C (auth: AC)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96EL2 Pfam ID:PF14955

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S5, mit
Gene (Uniprot):MRPS5
Chain IDs:D (auth: AD)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82675 Pfam ID:PF21251, PF00333, PF03719

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S6, mit
Gene (Uniprot):MRPS6
Chain IDs:E (auth: AE)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82932 Pfam ID:PF01250

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S7, mit
Gene (Uniprot):MRPS7
Chain IDs:F (auth: AF)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y2R9 Pfam ID:PF00177

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S9, mit
Gene (Uniprot):MRPS9
Chain IDs:G (auth: AG)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82933 Pfam ID:PF00380

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S10, mi
Gene (Uniprot):MRPS10
Chain IDs:H (auth: AH)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82664 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S11, mi
Gene (Uniprot):MRPS11
Chain IDs:I (auth: AI)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82912 Pfam ID:PF00411

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S12, mi
Gene (Uniprot):MRPS12
Chain IDs:J (auth: AJ)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O15235 Pfam ID:PF00164

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S14, mi
Gene (Uniprot):MRPS14
Chain IDs:K (auth: AK)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O60783 Pfam ID:PF00253

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S15, mi
Gene (Uniprot):MRPS15
Chain IDs:L (auth: AL)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82914 Pfam ID:PF00312

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S16, mi
Gene (Uniprot):MRPS16
Chain IDs:M (auth: AM)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y3D3 Pfam ID:PF00886

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S17, mi
Gene (Uniprot):MRPS17
Chain IDs:N (auth: AN)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y2R5 Pfam ID:PF00366

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S18b, m
Gene (Uniprot):MRPS18B
Chain IDs:O (auth: AO)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y676 Pfam ID:PF01084

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S18c, m
Gene (Uniprot):MRPS18C
Chain IDs:P (auth: AP)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y3D5 Pfam ID:PF01084

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:MRPS21 isoform 1
Gene (Uniprot):MRPS21
Chain IDs:Q (auth: AQ)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:A0A2J8VEN6 Pfam ID:PF01165

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S22, mi
Gene (Uniprot):MRPS22
Chain IDs:R (auth: AR)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82650 Pfam ID:PF10245

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S23, mi
Gene (Uniprot):MRPS23
Chain IDs:S (auth: AS)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y3D9 Pfam ID:PF10484

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S25, mi
Gene (Uniprot):MRPS25
Chain IDs:T (auth: AT)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P82663 Pfam ID:PF05047

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S26, mi
Gene (Uniprot):MRPS26
Chain IDs:U (auth: AU)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BYN8 Pfam ID:PF14943

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S27, mi
Gene (Uniprot):MRPS27
Chain IDs:V (auth: AV)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q92552 Pfam ID:PF10037

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S28, mi
Gene (Uniprot):MRPS28
Chain IDs:W (auth: AW)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y2Q9 Pfam ID:PF10246

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S29, mi
Gene (Uniprot):DAP3
Chain IDs:X (auth: AX)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P51398 Pfam ID:PF10236

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S31, mi
Gene (Uniprot):MRPS31
Chain IDs:Y (auth: AY)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q92665 Pfam ID:PF15433

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S33, mi
Gene (Uniprot):MRPS33
Chain IDs:Z (auth: AZ)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y291 Pfam ID:PF08293

Polymer Type:polyribonucleotide
Molecule:A/A-tRNA
Chain IDs:FA (auth: Aw)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:P/P-tRNA
Chain IDs:GA (auth: Ax)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:E/E-tRNA
Chain IDs:HA (auth: Ay)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:mRNA
Chain IDs:IA (auth: Az)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:mitochondrial tRNAVal
Chain IDs:KA (auth: B)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L2, mit
Gene (Uniprot):MRPL2
Chain IDs:LA (auth: D)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q5T653 Pfam ID:PF00181, PF03947

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L3, mit
Gene (Uniprot):MRPL3
Chain IDs:MA (auth: E)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P09001 Pfam ID:PF00297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L4, mit
Gene (Uniprot):MRPL4
Chain IDs:NA (auth: F)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BYD3 Pfam ID:PF00573

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L9, mit
Gene (Uniprot):MRPL9
Chain IDs:OC (auth: H)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BYD2 Pfam ID:PF01281, PF22078, PF25131

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L10, mi
Gene (Uniprot):MRPL10
Chain IDs:OA (auth: I)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q7Z7H8 Pfam ID:PF00466

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L11, mi
Gene (Uniprot):MRPL11
Chain IDs:PA (auth: J)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y3B7 Pfam ID:PF03946, PF00298

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L13, mi
Gene (Uniprot):MRPL13
Chain IDs:QA (auth: K)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BYD1 Pfam ID:PF00572

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L14, mi
Gene (Uniprot):MRPL14
Chain IDs:RA (auth: L)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q6P1L8 Pfam ID:PF00238

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L15, mi
Gene (Uniprot):MRPL15
Chain IDs:SA (auth: M)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9P015 Pfam ID:PF00828

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L16, mi
Gene (Uniprot):MRPL16
Chain IDs:TA (auth: N)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NX20 Pfam ID:PF00252

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L17, mi
Gene (Uniprot):MRPL17
Chain IDs:UA (auth: O)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NRX2 Pfam ID:PF01196

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L18, mi
Gene (Uniprot):MRPL18
Chain IDs:VA (auth: P)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9H0U6 Pfam ID:PF00861

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L19, mi
Gene (Uniprot):MRPL19
Chain IDs:WA (auth: Q)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P49406 Pfam ID:PF01245

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L20, mi
Gene (Uniprot):MRPL20
Chain IDs:XA (auth: R)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BYC9 Pfam ID:PF00453

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L21, mi
Gene (Uniprot):MRPL21
Chain IDs:YA (auth: S)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q7Z2W9 Pfam ID:PF00829

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L22, mi
Gene (Uniprot):MRPL22
Chain IDs:ZA (auth: T)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NWU5 Pfam ID:PF00237

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L23, mi
Gene (Uniprot):MRPL23
Chain IDs:AB (auth: U)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q16540 Pfam ID:PF00276

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L24, mi
Gene (Uniprot):MRPL24
Chain IDs:BB (auth: V)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96A35 Pfam ID:PF00467, PF17136

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L27, mi
Gene (Uniprot):MRPL27
Chain IDs:CB (auth: W)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9P0M9 Pfam ID:PF01016

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L28, mi
Gene (Uniprot):MRPL28
Chain IDs:DB (auth: X)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13084 Pfam ID:PF00830

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L47, mi
Gene (Uniprot):MRPL47
Chain IDs:EB (auth: Y)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9HD33 Pfam ID:PF06984

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L30, mi
Gene (Uniprot):MRPL30
Chain IDs:FB (auth: Z)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8TCC3 Pfam ID:PF00327

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L42, mi
Gene (Uniprot):MRPL42
Chain IDs:QB (auth: a)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9Y6G3 Pfam ID:PF10210

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):MRPL43
Chain IDs:RB (auth: b)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8N983 Pfam ID:PF05047

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L44, mi
Gene (Uniprot):MRPL44
Chain IDs:SB (auth: c)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9H9J2 Pfam ID:PF22935, PF22892 EC:3.1.26.-

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L45, mi
Gene (Uniprot):MRPL45
Chain IDs:TB (auth: d)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BRJ2 Pfam ID:PF04280

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L46, mi
Gene (Uniprot):MRPL46
Chain IDs:UB (auth: e)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9H2W6 Pfam ID:PF11788

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L48, mi
Gene (Uniprot):MRPL48
Chain IDs:VB (auth: f)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96GC5 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L49, mi
Gene (Uniprot):MRPL49
Chain IDs:WB (auth: g)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13405 Pfam ID:PF05046

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L50, mi
Gene (Uniprot):MRPL50
Chain IDs:XB (auth: h)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8N5N7 Pfam ID:PF10501

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L51, mi
Gene (Uniprot):MRPL51
Chain IDs:YB (auth: i)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q4U2R6 Pfam ID:PF10244

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L52, mi
Gene (Uniprot):MRPL52
Chain IDs:ZB (auth: j)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q86TS9 Pfam ID:PF18699

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L53, mi
Gene (Uniprot):MRPL53
Chain IDs:AC (auth: k)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q96EL3 Pfam ID:PF10780

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L54, mi
Gene (Uniprot):MRPL54
Chain IDs:BC (auth: l)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q6P161 Pfam ID:PF08561

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L55, mi
Gene (Uniprot):MRPL55
Chain IDs:CC (auth: m)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q7Z7F7 Pfam ID:PF09776

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein 63, mitocho
Gene (Uniprot):MRPL57
Chain IDs:DC (auth: o)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BQC6 Pfam ID:PF14978

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Peptidyl-tRNA hydrolase ICT1,
Gene (Uniprot):MRPL58
Chain IDs:EC (auth: p)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q14197 Pfam ID:PF00472 EC:3.1.1.29

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Growth arrest and DNA damage-
Gene (Uniprot):GADD45GIP1
Chain IDs:FC (auth: q)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q8TAE8 Pfam ID:PF10147

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein S18a, m
Gene (Uniprot):MRPS18A
Chain IDs:GC (auth: r)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NVS2 Pfam ID:PF01084

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein S30, mi
Gene (Uniprot):MRPS30
Chain IDs:HC (auth: s)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9NP92 Pfam ID:PF07147

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L12, mi
Gene (Uniprot):MRPL12
Chain IDs:IC (auth: t), JC (auth: u), KC (auth: v), LC (auth: w), MC (auth: x), NC (auth: y)
Chain Length:0
Number of Molecules:6
Biological Source:Homo sapiens

UniProt ID:P52815 Pfam ID:PF16320, PF00542

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L1, mit
Gene (Uniprot):MRPL1
Chain IDs:PC (auth: z)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9BYD6 Pfam ID:PF00687

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details
1MA	JA	A	modified residue
2MG	KA	G	modified residue
5MC	A	C	modified residue
5MU	A	U	modified residue
AYA	Q	ALA	modified residue
B8T	A	C	modified residue
MA6	A	A	modified residue
OMG	JA	G	modified residue
OMU	JA	U	modified residue
PSU	JA	U	modified residue
SAC	QA	SER	modified residue

Ligand Molecules

ATP

FES

GDP

NAD

PUT

SPD

SPM

VAL

Primary Citation

Mitoribosome structure with cofactors and modifications reveals mechanism of ligand binding and interactions with L1 stalk.

Singh, V, Itoh, Y, Del'Olio, S, Hassan, A, Naschberger, A, Flygaard, R.K, Nobe, Y, Izumikawa, K, Aibara, S, Andrell, J, Whitford, P.C, Barrientos, A, Taoka, M, Amunts, A.Show

Nat Commun 15 4272 4272 (2024)

PMID: 38769321 DOI: 10.1038/s41467-024-48163-x

Abstact

The mitoribosome translates mitochondrial mRNAs and regulates energy conversion that is a signature of aerobic life forms. We present a 2.2 Å resolution structure of human mitoribosome together with validated mitoribosomal RNA (rRNA) modifications, including aminoacylated CP-tRNAVal. The structure shows how mitoribosomal proteins stabilise binding of mRNA and tRNA helping to align it in the decoding center, whereas the GDP-bound mS29 stabilizes intersubunit communication. Comparison between different states, with respect to tRNA position, allowed us to characterize a non-canonical L1 stalk, and molecular dynamics simulations revealed how it facilitates tRNA transitions in a way that does not require interactions with rRNA. We also report functionally important polyamines that are depleted when cells are subjected to an antibiotic treatment. The structural, biochemical, and computational data illuminate the principal functional components of the translation mechanism in mitochondria and provide a description of the structure and function of the human mitoribosome.

Legend

Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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