ISDA: 6YWX

Deposition Date 2020-04-30

Release Date 2020-11-11

Last Version Date 2024-10-23

Entry Detail

PDB ID:

6YWX

Keywords:

TRANSLATION

Title:

The structure of the mitoribosome from Neurospora crassa with tRNA bound to the E-site

Biological Source:

Source Organism(s):

Neurospora crassa OR74A (Taxon ID: 367110)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.10 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein
Gene (Uniprot):rtc6
Chain IDs:BA (auth: 0)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S4E7 Pfam ID:PF00444

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:IF1
Gene (Uniprot):inh1
Chain IDs:ZB (auth: 00), AC (auth: 99)
Chain Length:0
Number of Molecules:2
Biological Source:Neurospora crassa OR74A

UniProt ID:V5IRA3 Pfam ID:PF04568

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial large ribosomal
Gene (Uniprot):mrpl35
Chain IDs:CA (auth: 1)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RXV8 Pfam ID:PF01161

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:37S ribosomal protein mrp10,
Gene (Uniprot):mrp10
Chain IDs:RB (auth: 11)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S4Y4

Polymer Type:polypeptide(L)
Molecule:mL40
Chain IDs:DA (auth: 2)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:DUF1713 domain-containing pro
Gene (Uniprot):cox24
Chain IDs:SB (auth: 22)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SHR6 Pfam ID:PF08213

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL41
Gene (Uniprot):mrpl27
Chain IDs:EA (auth: 3)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S5W0 Pfam ID:PF09809

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:IGR domain-containing protein
Gene (Uniprot):fyv4
Chain IDs:TB (auth: 33)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K6Q3 Pfam ID:PF09597

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):mrpl51
Chain IDs:FA (auth: 4)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S300 Pfam ID:PF05047

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Fe superoxide dismutase
Gene (Uniprot):rsm26
Chain IDs:UB (auth: 44), VB (auth: 55)
Chain Length:0
Number of Molecules:2
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S2H6 Pfam ID:PF02777

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L3
Gene (Uniprot):mrpl3
Chain IDs:GA (auth: 5)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SA88 Pfam ID:PF00035, PF22892

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:50S ribosomal subunit L30
Gene (Uniprot):mrpl17
Chain IDs:HA (auth: 6)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S1Z3 Pfam ID:PF11788, PF00293

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS45
Gene (Uniprot):mrps35
Chain IDs:WB (auth: 66)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SHB2 Pfam ID:PF12298

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL49
Gene (Uniprot):img2
Chain IDs:IA (auth: 7)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S518 Pfam ID:PF05046

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS46
Gene (Uniprot):rsm28
Chain IDs:XB (auth: 77)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SG49

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL50
Gene (Uniprot):mrpl13
Chain IDs:JA (auth: 8)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S711 Pfam ID:PF10501

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:3-hydroxyisobutyryl-CoA hydro
Gene (Uniprot):ehd3
Chain IDs:YB (auth: 88)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K7A4 Pfam ID:PF16113 EC:3.1.2.4

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:RNase III domain-containing p
Gene (Uniprot):mrpl15
Chain IDs:MA (auth: 9)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S1R6 Pfam ID:PF14622

Polymer Type:polyribonucleotide
Molecule:23S rRNA
Chain IDs:A
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bS1m
Gene (Uniprot):mrp51
Chain IDs:RA (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:A7UWX2 Pfam ID:PF11709

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L2
Gene (Uniprot):rml2
Chain IDs:B
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SCX7 Pfam ID:PF00181, PF03947

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mito ribosomal protein S2
Gene (Uniprot):mrp4
Chain IDs:SA (auth: BB)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:V5ILE0 Pfam ID:PF00318

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L3
Gene (Uniprot):mrpl9
Chain IDs:C
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K8T6 Pfam ID:PF00297

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein S5, mitocho
Gene (Uniprot):var1
Chain IDs:TA (auth: CC)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:P23351

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L4, var
Gene (Uniprot):yml6
Chain IDs:D
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:V5IMN1 Pfam ID:PF00573

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mito ribosomal protein S4
Gene (Uniprot):NAM9
Chain IDs:UA (auth: DD)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SA90 Pfam ID:PF01479

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:50S ribosomal protein L5
Gene (Uniprot):mrpl7
Chain IDs:E
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K6P0 Pfam ID:PF00673

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:37S ribosomal protein S5
Gene (Uniprot):mrps5
Chain IDs:VA (auth: EE)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K548 Pfam ID:PF00333, PF03719

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L6
Gene (Uniprot):mrpl6
Chain IDs:F
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RZF0 Pfam ID:PF00347

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mito ribosomal protein S6
Gene (Uniprot):mrp17
Chain IDs:WA (auth: FF)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SB95 Pfam ID:PF01250

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:RIBOSOMAL_L9 domain-containin
Gene (Uniprot):mrpl50
Chain IDs:G
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S054 Pfam ID:PF01281

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal_S7 domain-containin
Gene (Uniprot):rsm7
Chain IDs:XA (auth: GG)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S6M9 Pfam ID:PF00177

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein L13
Gene (Uniprot):mrpl23
Chain IDs:J (auth: H)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SBV6 Pfam ID:PF00572

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S8
Gene (Uniprot):mrps8
Chain IDs:YA (auth: HH)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SHF3 Pfam ID:PF00410

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:50S ribosomal protein L14
Gene (Uniprot):mrpl38
Chain IDs:K (auth: I)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SBJ8 Pfam ID:PF00238

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:37S ribosomal protein S9, mit
Gene (Uniprot):mrp-9
Chain IDs:ZA (auth: II)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S7R6 Pfam ID:PF00380

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:50S ribosomal subunit protein
Gene (Uniprot):mrpl10
Chain IDs:L (auth: J)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SB98 Pfam ID:PF00828

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:37S ribosomal protein S10, mi
Gene (Uniprot):mrp-10
Chain IDs:AB (auth: JJ)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RYL4 Pfam ID:PF00338

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L16
Gene (Uniprot):mrpl16
Chain IDs:M (auth: K)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:F5HIJ5 Pfam ID:PF00252

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):mrps18
Chain IDs:BB (auth: KK)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SGU0 Pfam ID:PF00411

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:50S ribosomal protein L17
Gene (Uniprot):mrpl8
Chain IDs:N (auth: L)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K8C8 Pfam ID:PF01196

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial 30S ribosomal p
Gene (Uniprot):mrps12
Chain IDs:CB (auth: LL)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S9I4 Pfam ID:PF00164

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):img1
Chain IDs:O (auth: M)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RYW8 Pfam ID:PF01245

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:40S ribosomal protein S13
Gene (Uniprot):sws2
Chain IDs:DB (auth: MM)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S2C2 Pfam ID:PF00416

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Aconitate hydratase
Gene (Uniprot):mrpl49
Chain IDs:P (auth: N)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SGE5 Pfam ID:PF00829

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial 40S ribosomal p
Gene (Uniprot):mrp2
Chain IDs:EB (auth: NN)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SF85 Pfam ID:PF00253

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial large ribosomal
Gene (Uniprot):mrpl22
Chain IDs:Q (auth: O)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S5N0 Pfam ID:PF00237

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein S15
Gene (Uniprot):mrps28
Chain IDs:FB (auth: OO)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K5G1 Pfam ID:PF00312

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):mrp20
Chain IDs:R (auth: P)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SA60 Pfam ID:PF00276

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ribosomal protein S16, mitoch
Gene (Uniprot):cyt-21
Chain IDs:GB (auth: PP)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:P08580 Pfam ID:PF00886

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:KOW domain-containing protein
Gene (Uniprot):mrpl40
Chain IDs:S (auth: Q)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RXU7 Pfam ID:PF22682, PF00467

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial 37S ribosomal p
Gene (Uniprot):mrps17
Chain IDs:HB (auth: QQ)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S4E0 Pfam ID:PF00366

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bL27m
Gene (Uniprot):mrp7
Chain IDs:T (auth: R)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K730 Pfam ID:PF01016

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mito ribosomal protein S18
Gene (Uniprot):rsm18
Chain IDs:IB (auth: RR)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K8E0 Pfam ID:PF01084

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:50S ribosomal protein L24
Gene (Uniprot):mrpl24
Chain IDs:U (auth: S)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SC44 Pfam ID:PF00830

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):rsm19
Chain IDs:JB (auth: SS)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K8V2 Pfam ID:PF00203

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:54S ribosomal protein L4, mit
Gene (Uniprot):mrpl4
Chain IDs:V (auth: T)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7S910 Pfam ID:PF06984

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mito ribosomal protein S21
Gene (Uniprot):mrp21
Chain IDs:KB (auth: TT)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SAJ1 Pfam ID:PF01165

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:50S ribosomal protein L30
Gene (Uniprot):mrpl33
Chain IDs:W (auth: U)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K8Y7 Pfam ID:PF00327

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:37S ribosomal protein S25, mi
Gene (Uniprot):rsm25
Chain IDs:LB (auth: UU)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q873E4 Pfam ID:PF13741

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bL31m
Gene (Uniprot):mrpl36
Chain IDs:X (auth: V)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K7L7 Pfam ID:PF21492

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS26
Gene (Uniprot):pet123
Chain IDs:MB (auth: VV)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SHR9 Pfam ID:PF26163

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):mrpl32
Chain IDs:Y (auth: W)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K4P1 Pfam ID:PF01783

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS27
Gene (Uniprot):mrp13
Chain IDs:NB (auth: WW)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RYW7

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:bL33m
Gene (Uniprot):mrpl39
Chain IDs:Z (auth: X)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:V5IM60 Pfam ID:PF00471

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):rsm23
Chain IDs:OB (auth: XX)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SD06 Pfam ID:PF10236

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Related to ribosomal protein
Gene (Uniprot):mrpl34
Chain IDs:AA (auth: Y)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K7P9 Pfam ID:PF00468

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mS33
Gene (Uniprot):rsm27
Chain IDs:PB (auth: YY)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K5R0 Pfam ID:PF08293

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:37S ribosomal protein S24, mi
Gene (Uniprot):rsm24
Chain IDs:QB (auth: ZZ)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K5Z0 Pfam ID:PF10213

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L20
Gene (Uniprot):mrpl20
Chain IDs:NA (auth: a)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K6U7 Pfam ID:PF12824

Polymer Type:polyribonucleotide
Molecule:16S rRNA
Chain IDs:BC (auth: aa)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial 60S ribosomal p
Gene (Uniprot):mrpl25
Chain IDs:OA (auth: b)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SEK9 Pfam ID:PF18126

Polymer Type:polyribonucleotide
Molecule:tRNA E-site
Chain IDs:CC (auth: bb)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:54S ribosomal protein L31, mi
Gene (Uniprot):mrpl31
Chain IDs:PA (auth: c)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:U9W8F2 Pfam ID:PF09784

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL67
Gene (Uniprot):mhr1
Chain IDs:QA (auth: d)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RYM5 Pfam ID:PF12829

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L1
Gene (Uniprot):mrpl1
Chain IDs:DC (auth: e)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q1K699 Pfam ID:PF00687

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:uL10m
Gene (Uniprot):mrpl11
Chain IDs:H (auth: f)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RZ62

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:60S ribosomal protein L19
Gene (Uniprot):mrpl19
Chain IDs:I (auth: g)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RX40 Pfam ID:PF03946, PF00298

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):mrpl44
Chain IDs:KA (auth: h)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SGH0 Pfam ID:PF10780

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:mL54
Gene (Uniprot):mrpl37
Chain IDs:LA (auth: i)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7SCZ3 Pfam ID:PF08561

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:L51_S25_CI-B8 domain-containi
Gene (Uniprot):mrp49
Chain IDs:EC (auth: j)
Chain Length:0
Number of Molecules:1
Biological Source:Neurospora crassa OR74A

UniProt ID:Q7RWZ7 Pfam ID:PF05047

Ligand Molecules

ATP

NAD

SPM

Primary Citation

Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi.

Itoh, Y, Naschberger, A, Mortezaei, N, Herrmann, J.M, Amunts, A.Show

Nat Commun 11 5187 5187 (2020)

PMID: 33056988 DOI: 10.1038/s41467-020-18830-w

Abstact

Mitoribosomes are specialized protein synthesis machineries in mitochondria. However, how mRNA binds to its dedicated channel, and tRNA moves as the mitoribosomal subunit rotate with respect to each other is not understood. We report models of the translating fungal mitoribosome with mRNA, tRNA and nascent polypeptide, as well as an assembly intermediate. Nicotinamide adenine dinucleotide (NAD) is found in the central protuberance of the large subunit, and the ATPase inhibitory factor 1 (IF1) in the small subunit. The models of the active mitoribosome explain how mRNA binds through a dedicated protein platform on the small subunit, tRNA is translocated with the help of the protein mL108, bridging it with L1 stalk on the large subunit, and nascent polypeptide paths through a newly shaped exit tunnel involving a series of structural rearrangements. An assembly intermediate is modeled with the maturation factor Atp25, providing insight into the biogenesis of the mitoribosomal large subunit and translation regulation.

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Protein

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Disease

Primary Citation of related structures

Abstact

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