ISDA: 6PXA

Deposition Date 2019-07-25

Release Date 2019-09-25

Last Version Date 2023-10-11

Entry Detail

PDB ID:

6PXA

Keywords:

TRANSFERASE

Title:

The crystal structure of chloramphenicol acetyltransferase-like protein from Vibrio fischeri ES114 in complex with taurocholic acid

Biological Source:

Source Organism(s):

Aliivibrio fischeri (strain ATCC 700601 / ES114) (Taxon ID: 312309)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.82 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Chloramphenicol acetyltransfe
Gene (Uniprot):VF_A0790
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L
Chain Length:221
Number of Molecules:12
Biological Source:Aliivibrio fischeri (strain ATCC 700601 / ES114)

UniProt ID:Q5DZD6 Pfam ID:PF00132 EC:2.3.1.28

Ligand Molecules

ACT

FMT

GOL

SO4

TCH

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc ? e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

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Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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