6AZI image
Deposition Date 2017-09-11
Release Date 2017-10-04
Last Version Date 2024-11-13
Entry Detail
PDB ID:
6AZI
Keywords:
HYDROLASE
Title:
1.75 Angstrom Resolution Crystal Structure of D-alanyl-D-alanine Endopeptidase from Enterobacter cloacae in Complex with Covalently Bound Boronic Acid
Biological Source:
Source Organism(s):
Enterobacter cloacae subsp. cloacae ATCC 13047 (Taxon ID: 716541)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.75 Å
R-Value Free:
0.23
R-Value Work:
0.18
R-Value Observed:
0.19
Space Group:
P 21 21 21
6AZI validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:D-alanyl-D-alanine endopeptid
Gene (Uniprot):ECL_03445
Chain IDs:A
Chain Length:285
Number of Molecules:1
Biological Source:Enterobacter cloacae subsp. cloacae ATCC 13047
UniProt ID:A0A0H3CN11 Pfam ID:PF00768
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
MSE A MET modified residue
Ligand Molecules
BO4
Primary Citation
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc ? e0020025 e0020025 (2025)
PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

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Primary Citation of related structures
6AZI
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