ISDA: 5USW

Deposition Date 2017-02-14

Release Date 2017-02-22

Last Version Date 2024-11-13

Entry Detail

PDB ID:

5USW

Keywords:

TRANSFERASE

Title:

The crystal structure of 7,8-dihydropteroate synthase from Vibrio fischeri ES114

Biological Source:

Source Organism(s):

Vibrio fischeri (strain ATCC 700601 / ES114) (Taxon ID: 312309)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.64 Å

R-Value Free:

0.20

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Dihydropteroate synthase
Gene (Uniprot):folP
Chain IDs:A, B, C, D
Chain Length:281
Number of Molecules:4
Biological Source:Vibrio fischeri (strain ATCC 700601 / ES114)

UniProt ID:Q5E7M1 Pfam ID:PF00809 EC:2.5.1.15

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
MSE	A	MET	modified residue

Ligand Molecules

ACT

FMT

GOL

Primary Citation

Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.

Inniss, N.L, Minasov, G, Chang, C, Tan, K, Kim, Y, Maltseva, N, Stogios, P, Filippova, E, Michalska, K, Osipiuk, J, Jaroszewki, L, Godzik, A, Savchenko, A, Joachimiak, A, Anderson, W.F, Satchell, K.J.F.Show

Microbiol Resour Announc ? e0020025 e0020025 (2025)

PMID: 40391899 DOI: 10.1128/mra.00200-25

Abstact

Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

Legend

Protein

Chemical

Disease

Primary Citation of related structures

Abstact

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