ISDA: 5NZI

Deposition Date 2017-05-14

Release Date 2018-04-18

Last Version Date 2024-10-16

Entry Detail

PDB ID:

5NZI

Keywords:

TRANSFERASE

Title:

Crystal structure of UDP-glucose pyrophosphorylase S374F mutant from Leishmania major in complex with UDP-glucose

Biological Source:

Source Organism(s):

Leishmania major (Taxon ID: 5664)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.05 Å

R-Value Free:

0.24

R-Value Work:

0.18

R-Value Observed:

0.19

Space Group:

C 2 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:UDP-glucose pyrophosphorylase
Gene (Uniprot):UGP
Mutagens:S374F
Chain IDs:A
Chain Length:505
Number of Molecules:1
Biological Source:Leishmania major

UniProt ID:Q4QDU3 Pfam ID:PF01704 EC:2.7.7.9

Ligand Molecules

EDO

UPG

Primary Citation

Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies

Cramer, J.T, Fuehring, J.I, Baruch, P, Bruetting, C, Knoelker, H.-J, Gerardy-Schahn, R, Fedorov, R.Show

Acs Catalysis 8 ? ? (2018)

DOI: 10.1021/acscatal.7b03714

Primary Citation of related structures

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