ISDA: 5KPO

Deposition Date 2016-07-05

Release Date 2016-12-21

Last Version Date 2024-03-20

Entry Detail

PDB ID:

5KPO

Keywords:

TRANSFERASE/TRANSFERASE INHIBITOR

Title:

Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.65 Å

R-Value Free:

0.30

R-Value Work:

0.23

R-Value Observed:

0.24

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Poly [ADP-ribose] polymerase
Gene (Uniprot):PARP1
Mutagens:V762A
Chain IDs:A, B
Chain Length:352
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P09874 Pfam ID:PF02877, PF00644 EC:2.4.2.30

Ligand Molecules

6WY

Primary Citation

Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor

Cao, R, Wang, Y.L, Zhou, J, Yao, H.P, Huang, N, Xu, B.L.Show

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