ISDA: 46GH

Deposition Date 2026-09-21

Release Date 2026-10-28

Last Version Date 2026-10-28

Entry Detail

PDB ID:

46GH

Keywords:

DE NOVO PROTEIN

Title:

Crystal structure of a de novo-designed VHH targeting BHRF1

Biological Source:

Source Organism(s):

Epstein-barr virus strain ag876 (Taxon ID: 82830)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli, Cricetulus griseus

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.40 Å

R-Value Free:

0.25

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

P 2 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Apoptosis regulator BHRF1
Gene (Uniprot):BHRF1
Chain IDs:A, C, E, G, I, K, M, O, Q, S
Chain Length:160
Number of Molecules:10
Biological Source:Epstein-barr virus strain ag876

UniProt ID:P0C6Z1

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:BHRF1_VHH-N13
Chain IDs:B, D, F, H, J, L, N, P, R, T
Chain Length:132
Number of Molecules:10
Biological Source:synthetic construct

Ligand Molecules

Primary Citation

High-Affinity Protein Binder Design via Flow Matching and In Silico Maturation

Yu, Q.L, Guo, L.Y, Qin, X.Y, Huang, X.K, Tian, B.H, Wang, H.Z, Liu, Y, Wang, S, Lang, Y.Z, Shen, Z.H.Y, Lin, J, Chen, M.C.Show

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Primary Citation of related structures

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