ISDA: 45IC

Deposition Date 2026-08-29

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

45IC

Keywords:

VIRAL PROTEIN/IMMUNE SYSTEM

Title:

Complex structure of THZ-65 Fab bound to SARS-CoV-1 RBD

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Severe acute respiratory syndrome-related coronavirus (Taxon ID: 694009)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.78 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:THZ-65 Fab Light chain
Chain IDs:A (auth: D), D (auth: A)
Chain Length:213
Number of Molecules:2
Biological Source:Homo sapiens

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Spike protein S1
Gene (Uniprot):S
Chain IDs:B (auth: E), E (auth: B)
Chain Length:194
Number of Molecules:2
Biological Source:Severe acute respiratory syndrome-related coronavirus

UniProt ID:P59594

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:THZ-65 Fab Heavy chain
Chain IDs:C (auth: F), F (auth: C)
Chain Length:230
Number of Molecules:2
Biological Source:Homo sapiens

Primary Citation

Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection.

Zhang, Q, Chen, P, Guo, F, Zhou, R, Guo, R, Ge, X, Yang, Q, Xie, X, Xia, W, Fan, J, Yang, Z, Xu, Y, Huang, H, Li, J, Wang, H, Liao, H, Shi, X, Liu, N, Chen, Y, Chen, Z, Ma, J, Wang, X, Zhang, T, Zhang, L.Show

Immunity ? ? ? (2026)

PMID: 42705227 DOI: 10.1016/j.immuni.2026.08.009

Primary Citation of related structures

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