ISDA: 3TD0

Deposition Date 2011-08-10

Release Date 2011-12-07

Last Version Date 2024-03-20

Entry Detail

PDB ID:

3TD0

Keywords:

RNA

Title:

Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.60 Å

R-Value Free:

0.25

R-Value Work:

0.22

Space Group:

P 21 21 21

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Macromolecular Entities

Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(*UP*UP*GP*CP*GP*UP*
Chain IDs:A, B
Chain Length:23
Number of Molecules:2
Biological Source:

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
5BU	A	U	5-BROMO-URIDINE-5'-MONOPHOSPHATE

Ligand Molecules

Primary Citation

A structural basis for the antibiotic resistance conferred by an A1408G mutation in 16S rRNA and for the antiprotozoal activity of aminoglycosides

Kondo, J.Show

Angew. Chem. Int. Ed. Engl. 51 465 468 (2012)

PMID: 22110016 DOI: 10.1002/anie.201106084

Abstact

Resistance explained: The crystal structures of the ribosomal decoding A site with an A1408G antibiotic-resistance mutation were solved in the presence and absence of the aminoglycoside geneticin (see structure, geneticin carbon framework in yellow). These structures show how bacteria acquire high-level resistance against aminoglycosides by the mutation.

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Primary Citation of related structures

Abstact

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