ISDA: 39GO

Deposition Date 2026-10-07

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

39GO

Keywords:

TRANSFERASE

Title:

Crystal structure of a bacterial DOT1L methyl-transferase in complex with S-adenosyl homocysteine

Biological Source:

Source Organism(s):

Legionella pneumophila (Taxon ID: 446)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.26

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 31 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Histone-lysine N-methyltransf
Gene (Uniprot):D1H98_04800
Chain IDs:A
Chain Length:227
Number of Molecules:1
Biological Source:Legionella pneumophila

UniProt ID:A0A3A6VYM1 EC:2.1.1.360

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
MLZ	A	LYS	modified residue

Ligand Molecules

SAH

Primary Citation

The bacterial effector LpDot1 methylates SFPQ to hijack paraspeckle dynamics and alternative splicing immune responses

Nicchi, S, Mondino, S, Rusniok, C, Mahtal, N, Raynal, B, ElJ, R, Quentin, G.G, Dalla Rizza, J, Larrieux, N, Martyn, J.E, Schoeler, H, Schmutz, S, Matondo, M, Buschiazzo, A, Buchrieser, C, Rolando, M.Show

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Primary Citation of related structures

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