ISDA: 38HK

Deposition Date 2026-08-27

Release Date 2026-09-16

Last Version Date 2026-09-16

Entry Detail

PDB ID:

38HK

Keywords:

LIGASE

Title:

Crystal structure of the transpeptidase domain of a Y422F mutant of PBP2 from Neisseria gonorrhoeae strain H041

Biological Source:

Source Organism(s):

Neisseria gonorrhoeae (Taxon ID: 485)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.60 Å

R-Value Free:

0.22

R-Value Work:

0.18

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Probable peptidoglycan D,D-tr
Gene (Uniprot):penA
Mutagens:Y422F
Chain IDs:A
Chain Length:330
Number of Molecules:1
Biological Source:Neisseria gonorrhoeae

UniProt ID:F2Z7K9 EC:3.4.16.4

Primary Citation

Energetic coupling of an active site residue in penicillin-binding protein 2 from Neisseria gonorrhoeae with a resistance-associated conformational switch in the beta3-beta4 loop

Stratton, C.M, Bala, S, Bivins, M.M, Nicholas, R.A, Davies, C.Show

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