37PY image
Deposition Date 2026-07-31
Release Date 2026-11-04
Last Version Date 2026-11-04
Entry Detail
PDB ID:
37PY
Keywords:
CONTRACTILE PROTEIN
Title:
Human beta-cardiac myosin S1 motor domain with the essential light chain in the pre-powerstroke state
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Aequorea victoria (Taxon ID: 6100)
Mus musculus (Taxon ID: 10090)
Expression System(s):
Mus musculus
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.20 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
37PY validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Myosin-7,Green fluorescent pr
Gene (Uniprot):MYH7, GFP
Chain IDs:A
Chain Length:1109
Number of Molecules:1
Biological Source:Homo sapiens, Aequorea victoria
UniProt ID:P12883,P42212
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Myosin light chain 1/3, skele
Gene (Uniprot):Myl1
Chain IDs:B
Chain Length:188
Number of Molecules:1
Biological Source:Mus musculus
UniProt ID:P05977
Ligand Molecules
ADP
MG
PO4
Primary Citation
The dilated cardiomyopathy E525K mutation stabilizes the cardiac myosin interacting-heads motif while activating the isolated motor domain.
Biorxiv ? ? ? (2026)
PMID: 42926450 DOI: 10.64898/2026.10.02.756299
Primary Citation of related structures
37PY
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