ISDA: 37OC

Deposition Date 2026-07-29

Release Date 2026-11-04

Last Version Date 2026-11-04

Entry Detail

PDB ID:

37OC

Keywords:

TRANSFERASE

Title:

PLK4-T170D (inactive) in complex with Cpd15

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.69 Å

R-Value Free:

0.19

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 65

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine/threonine-protein kina
Gene (Uniprot):PLK4
Chain IDs:A
Chain Length:278
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O00444 EC:2.7.11.21

Ligand Molecules

A1DQE

PO4

Primary Citation

Lead Optimization of an Aminopyrazole Scaffold to EXEL-1855, a Highly Selective PLK4 Inhibitor with Potent Antitumor Efficacy.

Gonciarz, R.L, Chang, T, St Amant, A.H, Jeong, J.W, Ng, D, Mishra, N.M, Bhattarai, S, Salvant, J.M, Chang, J.T, Jiang, F, Basavarajappa, H, Wang, Z, Cole, D, Nguyen, H.H, Chang, J.H, Kumar, A, Mok, L, Xu, W, Sanders, J.M, Gurbani, D, Gwinn, D.M, Sherer, B.A, Munoz, N.M, Kochansky, C, Murray, J.M, Finlay, H.J.Show

J.Med.Chem. 69 22637 22656 (2026)

PMID: 42917933 DOI: 10.1021/acs.jmedchem.6c01844

Primary Citation of related structures

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